Novartis drops antibiotic development program

first_imgEditor’s note: This story was updated on Jul 13 with comments from Kevin Outterson, JD.Antibiotic development efforts were dealt a blow yesterday when drug maker Novartis AG announced its decision to drop its antibacterial and antiviral research programs.The decision means Novartis will no longer be working on several antimicrobial projects currently in development.In an emailed statement explaining the move, the Switzerland-based company said “While the science for these programs is compelling, we have decided to prioritize our resources in other areas where we believe we are better positioned to develop innovative medicines that will have a positive impact for patients.”Before the decision was announced, Novartis was one of only a handful of large, research-based pharmaceutical companies still active in antibiotic research and development. In 2016, the company was among the signers of the Davos Declaration, a written commitment by more than 70 pharmaceutical and biotech companies to invest in research and development of innovative treatments and diagnostics to combat antibiotic-resistant bacteria.Large companies exitingThe decision to leave antibiotic development will result in 140 layoffs from the Novartis Institutes for Biomedical Research (NIBR) in Emeryville, Calif., according to reporting by Endpoint News, a website that covers the pharmaceutical industry.But more significantly, it means another large pharmaceutical company is getting out of antibiotic development at a time when new antibiotics are desperately needed. AstraZeneca Plc sold its antibiotics unit to Pfizer Inc. in 2016.”Novartis leaving innovation in antibiotics is unfortunate, as we still need effective replacement antibiotics, and Novartis has a few in development,” said Jayasree Iyer, PhD, executive director of the Access to Medicine Foundation. “They are in discussions to divest them, so hopefully there’s a suitable partner to complete their development.”According to the foundation’s recent Antimicrobial Resistance Benchmark 2018 report, Novartis had 32 antimicrobial projects in its pipeline as of 2016, seven of which were in the clinical stage of development. Among them are LFF571, an antibiotic targeting Clostridium difficile, and LYS228, an antibiotic with activity against carbapenem-resistant Enterobacteriaceae (CRE).”This is a growing problem of less innovators around who have the capacity to commercialize new antibiotics,” Iyer added. She noted that while there are several small biotech companies working on antibiotic research and development, many of these companies lack the ability to commercialize these drugs.Novartis added in its statement that it will continue discussions to produce, market, and sell antibiotics developed by smaller companies.”The need for these types of medicines is clear and to maximize the chances that these programs will one day help patients we are actively engaged in out-licensing discussions with companies focused on developing medicines in these areas,” the company said.Economic challenge of antibiotic developmentThe economic challenge of antibiotic development is one of the reasons frequently cited for the lack of new antibiotics. A new antibiotic that’s effective against CRE, for example, would be a significant and much-needed weapon in the fight against multidrug-resistant bacteria.But the medical community would want to reserve such a drug for infections that have no other treatment options, in order to prevent the development of resistance. As a result, the company that developed the antibiotic would be unlikely to sell enough of the drug to earn back its investment, much less make a profit.While there are efforts to provide smaller companies with a financial “push” to get new antibiotics through the early stages of clinical development, like CARB-X (the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator), antibiotic development advocates believe that market incentives that delink profits from sales volume are also needed.”The world desperately needs several global companies with an ironclad commitment to antibiotics,” said CARB-X Executive Director Kevin Outterson, JD. “This Novartis decision is entirely due to the broken business model for antibiotics.”These “pull” incentives could take the form of a market entry reward, in which the developer of a new antibiotic would receive a significant up-front payment (funded by governments and other sources), thereby reducing the need to maximize sales. Other ideas include granting companies extended patents for a new antibiotic, or allowing them to use patent extensions for other drugs they’ve developed. In return, companies would have to ensure that the new antibiotic is used responsibly, affordable, and widely accessible.The movement around pull incentives has been gaining steam. On Jun 26, the World Economic Forum issued a report calling on governments and pharmaceutical companies to collaborate on designing pull incentives. A few days later, Congressmen from Indiana and California introduced a bill in the US House of Representatives, called REVAMP,  that would award 12 months of market exclusivity for new drugs designated as priority antimicrobial products.”We need a powerful pull incentive, like REVAMP or a market entry reward, to keep the sector afloat,” said Outterson.The last new class of antibiotics was discovered and developed more than 30 years ago.See also:Jul 11 Endpoint News storyJun 29 CIDRAP News story “Bipartisan bill proposes new ‘pull’ incentives for priority antibiotics”Jun 26 CIDRAP News story “World Economic Forum seeks ‘pull’ incentives for new antibiotics”Jan 23 Access to Medicine Foundation Antimicrobial Resistance Benchmark 2018last_img read more

Challenge Bibendum – clean future around the corner

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

Russia Drops First Criminal Charges Against Arctic 30 Activist

first_imgRussia has dropped the first criminal charges against Arctic 30 activist Anthony Perrett.As Greenpeace reports, Mr. Perrett has requested an exit visa from the Federal Migration Service to allow him to leave Russia.Anthony is one of the people who were seized when the Greenpeace ship Arctic Sunrise was boarded after a peaceful protest at Gazprom’s drill platform in the Pechora Sea. They need exit visas because they were charged and then bailed inside Russia after they had been detained in international waters beyond Russia’s territorial waters.The Russian Parliament approved an amnesty decree last week freeing defendants who have been charged with hooliganism. It therefore included the Arctic 30 – the 28 Greenpeace International activists and two freelance journalists, who were arrested at Gazprom-operated Arctic oil platform three months ago.December 25, 2013; Image: Greenpeacelast_img read more

Ichthys topsides integration moving forward

first_imgThe topsides integration phase for the Ichthys LNG project’s central processing facility (CPF) is progressing well at the Samsung Heavy Industries shipyard in South Korea.On Saturday 27 June, the Inpex-operated project celebrated the lifting of a 6400 tonne module which incorporates the CPF’s main electrical and instrumentation rooms.The lift was executed by two synchronised cranes operating in tandem. The 62 metre-long, 46 metre-wide module was the seventh of eight modules required to complete the CPF topsides, Inpex said on Wednesday.The CPF is scheduled to be launched from the floating dock in the coming months, Inpex added.Once complete, the CPF will be towed 5600 kilometres to the Ichthys field in the Browse Basin, offshore Western Australia, where it be moored permanently to the seabed for the life of the $US34 billion LNG project.Gas and some condensate from the CPF will be sent through an 889 kilometre pipeline to the project’s onshore LNG facilities in Darwin. LNG World News Staff; Image: Inpexlast_img read more

Malibu Creek Hearing Set for March 1

first_imgThe U.S. Army Corps of Engineers, Los Angeles District, will hold a public hearing for the Draft Integrated Feasibility Report for the Malibu Creek Ecosystem Restoration Study on March 1 at the Las Virgenes Municipal Water District in Calabasas, California.The primary purpose of the proposed project is to provide a more natural sediment transport regime from the watershed to the shoreline and to restore aquatic and riparian habitat connectivity along Malibu Creek and its tributaries, USACE said in its announcement.Implementation of the proposed project is intended to sustain or enhance indigenous populations of aquatic and terrestrial species within the next several decades, particularly the southern California steelhead, allowing for migratory opportunities to about 15 miles of habitat in this watershed that has been unreachable for over 90 years due to the presence of Rindge Dam.This project would support a key goal of the National Marine Fisheries Service’s Southern California Steelhead Recovery Plan, USACE said.The draft report includes formulation, evaluation and comparison of an array of alternatives with associated detailed environmental analyses and consequences.[mappress mapid=”23616″]last_img read more

Boskalis reaches agreement on Fairmount acquisition

first_imgHLPFI reported on December 27, 2013 that Boskalis was in talks with Fairmount Marine over a potential takeover.Fairmount operates five 205-tonne bollard pull tugs with anchor handling capabilities.The addition of the ocean going anchor handling tugs (AHTs) will allow Boskalis to further expand its market position in both offshore energy and salvage, says the company. The use of ocean going tugs for long distance wet towage is expected to complement Boskalis’ current dry heavy marine transport offering, and it hopes that it will now be able to offer its clients the full spectrum of heavy marine transport solutions tailored for the type of cargo or specific requirements.Boskalis has said that the acquisition is driven by the expansion of the global economy and increase in energy consumption.  www.boskalis.comwww.fairmount.nllast_img read more

A2SEA gets Sea Challenger ready

first_img“We are very proud of our new vessel,” says Jens Frederik Hansen, ceo at A2SEA. “The vessel is a sister to Sea Installer which has performed very well since her first project in January 2013.”Sea Challenger is equipped with a larger crane that is able to lift 900 tonnes compared to Sea Installer, which has a crane with 800 tonnes capacity. Otherwise the two vessels are virtually identical.The new ship will start installation on the Westermost Rough project in mid July, with Esbjerg as the loading port and the project team expects installation of the 35 turbines to be completed at the beginning of 2015. When Westermost Rough is fully commissioned, the wind farm will provide enough electricity to power around 200,000 homes.Photo by A2SEAwww.a2sea.comlast_img

Negrense pug competes in AIBA Championships

first_img[av_one_full first min_height=” vertical_alignment=” space=” custom_margin=” margin=’0px’ padding=’0px’ border=” border_color=” radius=’0px’ background_color=” src=” background_position=’top left’ background_repeat=’no-repeat’ animation=”][av_heading heading=’ Negrense pug competes in AIBA Championships ‘ tag=’h3′ style=’blockquote modern-quote’ size=’30’ subheading_active=’subheading_below’ subheading_size=’15’ padding=’10’ color=” custom_font=”]BY ADRIAN STEWART CO[/av_heading][av_textblock size=” font_color=” color=”]Saturdsy, August 19, 2017[/av_textblock][av_textblock size=’18’ font_color=” color=”]MANILA – Filipino amateur boxer Roden Ladon is up for a huge challenge at the 2017 AIBA World Boxing Championships from Aug. 25 to Sept. 3 in Hamburg, Germany. The Bago City, Negros Occidental-native light flyweight fighter will be one of the two Filipino boxers in the prestigious boxing tournament aside from flyweight Dannel Maamo.This is the second time Ladon will be competing in the tournament. He won a bronze medal at the AIBA World Boxing Championship two years ago in Doha, Qatar.“I have prepared hard for this tournament. My goal really is to duplicate, and if ever, surpass my bronze medal finish two years ago,” said Ladon.He also competed in the Rio de Janeiro Olympics last year.“I will really be aiming for a podium finish here in AIBA. I am motivated after my forgetful performance in Rio last year,” added the Negrense boxer. “I will really give it all to make the country proud.”National team head coach Boy Velasco said he sees both Ladon and Maamo performing well after the intense training in Baguio City.“They’re ready and they will do their best to make the country proud,” Velasco said. “They are seasoned internationalists and they’re used to fighting in the big stage, especially Ladon.”Ladon and Maamo booked a ticket to the AIBA World Championships after netting bronze medals at the 2017 Asian Boxing Confederation (ASBC) Asian Elite Championships last May in Tashkent, Uzbekistan./PN[/av_textblock][/av_one_full]last_img read more

Bacolod’s Agravante heads to Milo Marathon finals

first_imgAgravante failed to defend his title last year when he did not finish the race at the Cebu City Sports Complex.Meanwhile Christine Hallasgo of Malaybalay, Bukidnon dominated the women’s race in three hours, five minutes and 17 seconds. Trailing behind were Jho-an VIllarma and Cinderella Lorenzo.More Western Visayas-based marathoners are expected to qualify to the National Finals as Mandurriao, Iloilo City hosts the sixth qualifying leg on Oct. 7./PN Jeson Agravante, a native of Bacolod City, will try to regain the Milo Marathon title this year. MILO MANILA – Jeson Agravante returned to the National Finals of the 42nd Milo Marathon after ruling the men’s event in the Metro Manila leg.The Bacolod City native finished the 42-kilometer race in two hours, 35 minutes and 10 seconds – punching a ticket to the National Finals on Dec. 9 in Laoag City.Finishing behind Agravante – the National Finals champion two years ago – on Sunday are fellow Bacolodnon marathoners Erick Paniqui (second place) and Rolando Espina (fourth place).“I am thankful that I am back in the National Finals. I will try to regain the Milo Marathon King title,” said Agravante, who bagged P50,000 cash and a trophy for winning the leg in Pasay City.last_img read more

Bermula Dari DC-9, Inilah Rentetan Fakta Unik Seputar Turkish Airlines

first_imgTidak seperti Qatas Airways dan Emirates yang memilih untuk menjadi sponsor utama dari dua raksasa sepak bola, FC Barcelona dan Real Madrid, Turkish Airlines lebih memilih untuk menampilkan Lionel Messi dan Kobe Bryant di salah satu iklannya. Ya, dua ikon di dunia olahraga ini dipilih menjadi ujung tombak dari strategi marketing dari Turkish Airlines.Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading… RelatedTurkish Airlines Kembali Layani Penerbangan Jakarta-Istanbul 2 Kali Seminggu07/07/2020In “Destinasi”Aeroflot – Ternyata Jadi Maskapai dengan Jumlah Armada Terbesar di Dunia17/10/2018In “Featured”Japan Airlines, Flag Carrier Jepang yang Jadi Pengguna Terbanyak Boeing 747 di Asia16/10/2018In “Featured” Sumber: Dari namanya saja, pasti Anda sudah tahu maskapai ini berasal dari mana. Ya, Turkish Airlines merupakan Flag Carrier Turki yang lahir pada 20 Mei 1933. Maskapai berkode THY versi ICAO ini digadang-gadang sebagai maskapai dengan destinasi penerbangan paling banyak, lho! Untuk memperkuat jaringan penerbangannya, Turkish Airlines lalu memutuskan untuk bergabung dengan aliansi penerbangan terbesar di dunia, Star Alliance.Baca: DC-9/MD-80, Pesawat Penumpang yang Mampu Melakukan Self-Pusback!Wah, kira-kira ada fakta apalagi ya dari maskapai yang bermarkas di Istanbul Atatürk Airport ini? Fasten your seatbelt, karena akan himpun beberapa fakta unik dari Turkish Airlines, dikutip dari laman! Berawal dari 5 Pesawat PropellerKetika pertama kali berdiri pada tahun 1933, Turkish Airlines hanya memiliki 5 pesawat propeller saja – dimana masing-masing hanya bisa menampung penumpang tidak lebih dari 7 orang saja. Namun seiring berjalannya waktu, maskapai ini terus bertumbuh kembang menjadi salah satu raksasa di dunia aviasi global.Jet Pertama Turkish Airlines Adalah…McDonnell Douglas DC-9 merupakan pesawat jet pertama yang dimiliki oleh Turkish Airlines. Diketahui, bergabungnya armada perdana ini pada tahun 1967 merupakan awal dari menanjaknya karir dari maskapai ini. Empat tahun berselang, Turkish Airlines kembali mendatangkan tiga armada Boeing 707 untuk menambah daya gedor dari maskapai ini.Ekspansi Besar-Besaran di Benua HitamDiantara maskapai-maskapai lain di seluruh penjuru dunia, Turkish Airlines tercatat sebagai maskapai yang paling sporadis dalam upayanya untuk melebarkan sayap di Benua Afrika. Pada akhir tahun 2015 silam, Turkish Airlines secara resmi mengumumkan bahwa Durban yang terletak di Afrika Selatan merupakan destinasi ke-45 di Benua Hitam.Baca Juga: Survei: 89 Persen Penumpang Turkish Airlines Tak Inginkan Adanya Panggilan Telepon Selama PenerbanganIklan Turkish Airlines Dibintangi Oleh Dua Legenda Olahragalast_img read more